Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl_4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. Objective: To investigate the hepatoprotective potential of Solonum xanthocarpum (Solanaceae) (S. xanthocarpum) in experimental rats to validate its traditional claim. Methods: 50% ethanolic fruit extract of S. xanthocarpum (SXE, 100.200 or 400 mg / kg hods weight) was administered daily for 14 davs in experimental animals.Liver injury was induced chemically, by CCl_4 administration (1 mL / kg ip). The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT) In vivo antioxidant activities as lipid peroxidation (LPO), reduced glutathione (GSH) .superoxide dismutase (SOD) and calalase (CAT) were screened along with histopathological studies. Results: Obtained results in that that the treatment with SXE significantly (P <0.05- <0.001) and dose-dcpendcntly been chemically induced increase in serum levels of hepatic enzymes .Furthermore.SXE significantly (up to P <0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defense antioxidant enzymes GSH, SOU and catalasc towards normal levels. Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions: The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity, and there by scientifically support its traditional use.