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目的 :探讨几种常用灌注药物预防膀胱癌术后复发的疗效。方法 :将 93例患者分为 3组 ,第一组用丝裂霉素 C 2 0 mg,第二组用卡介苗 (BCG) 6 0 m g,第三组用 BCG6 0 m g加白细胞介素 - 2 (IL - 2 ) 10 0 0 0 u行膀胱灌注。结果 :随访 6～ 72个月 ,平均 30 .5个月 ,肿瘤复发率第一组为 2 4.1% (7/ 2 9) ,第二组为 2 0 .0 % (6 / 30 ) ,第三组为8.8% (3/ 34)。第三组与前两组比较有显著性差异 (P <0 .0 1)。结论 :丝裂霉素 C、BCG及 BCG加 IL - 2膀胱灌注预防膀胱癌术后复发 ,疗效十分肯定 ,其中 BCG加 IL - 2灌注效果更好
Objective: To investigate the efficacy of several commonly used drugs to prevent postoperative recurrence of bladder cancer. Methods: Ninety - three patients were divided into three groups: the first group received mitomycin C 2 0 mg, the second group received BCG 60 mg, the third group received BCG 60 mg plus interleukin - 2 ( IL - 2) 10 000 u bladder irrigation. Results: The follow-up ranged from 6 to 72 months, with an average of 30.5 months. The recurrence rate in the first group was 21.1% (7/29) in the first group, 20.0% (6/30) in the second group, The group was 8.8% (3/34). The third group and the first two groups were significantly different (P <0. 01). CONCLUSION: Mitomycin C, BCG and BCG combined with intravesical instillation of IL - 2 prevent postoperative recurrence of bladder cancer, and the curative effect is very good. The effect of BCG plus IL - 2 perfusion is better