肾上腺素受体亚型分为三大类９个亚型，α１受体（α１Ａ，α１Ｂ，α１Ｄ）、α２受体（α２Ａ，α２Ｂ，α２Ｃ）和β受体（β１，β２，β３）。新亚型的确切功能尚不十分清楚，但生物学效应均由Ｇ蛋白所介导：α１－ＡＲ主要偶联Ｇαｑ，α２－ＡＲ主要偶联Ｇαｉ，β－ＡＲ主要偶联Ｇαｓ。各亚型既受到许多因素的调节，同时又产生交互作用。激动剂长期作用于ＡＲ，可引起受体的同源性脱敏或异源性脱敏。肾上腺素受体基因遗传改变在心血管病的发生、发展过程中起着重要作用 The adrenergic receptor subtype is divided into three major subtypes, nine subtypes, α1 receptors (α1A, α1B, α1D), α2 receptors (α2A, α2B, α2C) and β receptors (β1, β2, β3). The exact function of the new subtype is not well understood, but the biological effects are mediated by the G protein: α1-AR is primarily coupled to Gαq, α2-AR is primarily coupled to Gαi, and β-AR is primarily coupled to Gαs. Subtypes are regulated by many factors at the same time as they interact. Long-term agonist effect on AR, can cause homology desensitization or heterologous desensitization. Adrenergic receptor gene genetic changes play an important role in the occurrence and development of cardiovascular diseases