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肝素钠系自猪或牛的肠粘膜中提取的硫酸氨基葡聚糖的钠盐,属粘多糖类物质,具有延长血凝时间的作用。肝素钠的含量测定中国药典1995年版二部规定为生物检定法,因费时费力,不适合医院制剂的中间品质量控制。本文根据肝素钠具有比旋度的特点,用旋光法对本院自制制剂肝素钠稀释液进行含量测定。本法简便易行,结果满意,现报道如下。
Heparin sodium is derived from the intestinal mucosa of pigs or cattle and the sodium salt of aminodextran sulfate is a mucopolysaccharide substance with the effect of prolonging the hemagglutination time. Determination of heparin sodium Chinese Pharmacopoeia 1995 edition of the provisions of the two biological test method, due to time-consuming and laborious, not suitable for intermediate quality control of hospital preparations. In this paper, based on the characteristics of heparin sodium with specific rotation, using optical rotation of the hospital homemade preparation of heparin sodium diluent content determination. This Law is simple and easy to use, the results are satisfactory, are reported below.