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目的观察马来酸依那普利(依苏)对老年高血压患者肾功能的影响。方法38例老年原发高血压患者,给予口服依苏5～10mg/d,分1～2次口服,治疗8～10周。观察治疗前后血压,24h尿蛋白,内生肌酐清除率,血尿素氮,血肌酐的变化。结果经8～10周的治疗,内生肌酐清除率增加,血尿素氮、24h尿蛋白、血肌酐降低,差异有统计学意义(P<0.05)。结论依苏能改善高血压病肾功能,减少尿蛋白,有持续性抗高血压作用,且降压稳定,使用安全方便,不良反应小。
Objective To observe the effect of enalapril maleate (ESS) on renal function in elderly patients with hypertension. Methods Thirty-eight elderly patients with essential hypertension were given oral administration of 5 ~ 10mg / d orally, and were orally administered once or twice for 8-10 weeks. Blood pressure, 24h urine protein, creatinine clearance rate, blood urea nitrogen, serum creatinine were observed before and after treatment. Results After 8 to 10 weeks of treatment, the rate of endogenous creatinine clearance increased, blood urea nitrogen, 24 h urinary protein, serum creatinine decreased, the difference was statistically significant (P <0.05). Conclusion Yi Su can improve renal function of hypertension, reduce urinary protein, have sustained antihypertensive effects, and stable blood pressure, the use of safe and convenient, small adverse reactions.