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目的探讨葡萄糖转运蛋白(GLUT1)和缺氧诱导因子-1α(H IF-1α)表达与食管癌发生、发展及其生物学行为的关系。方法应用免疫组织化学SP法检测60例食管癌及其癌旁不典型增生组织、上切缘正常食管粘膜中GLUT1和H IF-1α的表达。结果GLUT1在食管癌癌组织、癌旁不典型增生组织及正常食管粘膜组织中的阳性表达率分别为91.67%、58.82%和20.00%,三组间两两比较,差异均有统计学意义(P<0.01);三组的强阳性表达率分别为78.18%、40.00%和8.33%,三组间两两比较,差异亦均有统计学意义(P<0.05)。H IF-1α在食管癌癌组织、癌旁不典型增生组织及正常食管粘膜组织中的阳性表达率分别为80.00%、38.24%和6.67%,三组间两两比较,差异均有统计学意义(P<0.05);三组的强阳性表达率分别为81.25%、38.46%和0.00%,三组间两两比较,差异亦均有统计学意义(P<0.05)。结论GLUT1和H IF-1α蛋白的过度表达可能共同参与了食管癌的发生、发展过程。
Objective To investigate the relationship between the expression of glucose transporter (GLUT1) and hypoxia inducible factor-1α (HIF-1α) and the occurrence, development and biological behavior of esophageal cancer. Methods Immunohistochemical SP method was used to detect the expression of GLUT1 and HIF-1α in 60 cases of esophageal cancer and its adjacent atypical hyperplasia tissues. Results The positive rates of GLUT1 expression in esophageal cancer tissues, atypical hyperplasia tissues and normal esophageal mucosa tissues were 91.67%, 58.82% and 20.00%, respectively, with significant differences between the three groups (P <0.01). The strong positive expression rates of the three groups were 78.18%, 40.00% and 8.33% respectively. The differences among the three groups were also statistically significant (P <0.05). The positive expression rates of HIF-1α in esophageal cancer tissues, adjacent atypical hyperplasia tissues and normal esophageal mucosa tissues were 80.00%, 38.24% and 6.67%, respectively, and the differences among the three groups were statistically significant (P <0.05). The strong positive expression rates of the three groups were 81.25%, 38.46% and 0.00% respectively. The differences among the three groups were also statistically significant (P <0.05). Conclusion Overexpression of GLUT1 and HIF-1α may participate in the carcinogenesis and progression of esophageal cancer.