该院神经外科主任赵继宗教授带领课题组经多年研究首次从分子水平证实,脑动脉瘤组织中72—和92—KDaⅣ型胶原酶含量明显增高。因这种酶体主要存在于单核细胞中,进而推测脑动脉瘤的发生与免疫反应密切相关。这项由国家自然科学基金资助的研究,为探索脑动脉瘤的发病机理提供了新的学说。 脑动脉瘤具有高致残率和高死亡率,因而被临床称之为“颅内炸弹”,其发病机理及破裂原因是医学界关注的热点之一。赵继宗教授 Professor Zhao Jizong, director of neurosurgery at the hospital, led the research group to prove for the first time from the molecular level after many years of research that the content of 72- and 92-KDa type Ⅳ collagenase in cerebral aneurysm tissues was significantly higher. Because of this body of the body mainly in mononuclear cells, and then speculated that the occurrence of cerebral aneurysms and immune response are closely related. This study funded by the National Natural Science Foundation provides a new theory for exploring the pathogenesis of cerebral aneurysms. Cerebral aneurysms with high morbidity and mortality, which is clinically called “intracranial bomb”, its pathogenesis and cause of rupture is one of the hot topics in the medical community. Professor Zhao Jizong