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目的综述近年雌激素及其受体在青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)发病中作用的研究进展。方法广泛查阅国内外与AIS病因中雌激素及其受体异常相关的临床资料与基础研究,并进行总结分析。结果大多数AIS患者体内存在雌激素及其受体异常,主要包括血清雌激素水平升高、细胞对雌激素反应性异常、月经初潮年龄延迟及核受体与膜受体基因多态性,而且与侧凸的易感性、严重程度和进展风险密切相关。结论雌激素及其受体通过不同病理机制在一定程度上参与了AIS的发生、发展,但机制尚不明确,仍有待进一步研究。
OBJECTIVE: To review the recent advances in the role of estrogen and its receptors in the pathogenesis of adolescent idiopathic scoliosis (AIS). Methods Extensive access to clinical data and basic research related to estrogen and its receptor abnormalities in AIS at home and abroad were summarized and analyzed. Results Most AIS patients had estrogen and its receptor abnormalities in vivo, including elevated serum estrogen levels, abnormal estrogen responsiveness to cells, delayed age of menarche and nuclear receptor and membrane receptor gene polymorphisms It is closely related to the susceptibility, severity and progress risk of scoliosis. Conclusions Estrogen and its receptors are involved in the occurrence and development of AIS to some extent through different pathological mechanisms. However, the mechanism of estrogen and its receptor remains unclear and remains to be further studied.