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目的探讨引起受压迫的猫视神经电生理学变化的最小伽玛刀剂量。方法制作20只猫视神经压迫动物模型,模型制成后2个月,随机分为5组,每组4只,1组作为对照,其余4组分别接受10、11、12、13 Gy伽玛刀的照射,照射后分别于3 d、1周、半个月、1、2、3、4、5个月进行电生理监测。结果10 Gy组在伽玛刀照射后1周内有电生理的变化,这种变化在半个月时有所恢复,随着时间的延长逐渐恢复。11 Gy以上组在伽玛刀照射后出现了不可逆电生理学的异常变化,这种变化随着时间的延长而加重。结论10 Gy可引起受压迫的猫视神经电生理学的可逆性变化,11 Gy可引起视神经不可逆的放射性损伤。
Objective To investigate the minimum dose of Gamma Knife that can cause the change of ophthalmologic electrophysiology in oppressed cats. Methods Twenty adult cats with ophthalmic ophthalmic compression were made. Two months after the model was made, they were randomly divided into 5 groups (4 in each group). One group served as control. The other 4 groups received 10, 11, 12 and 13 Gy gamma knife Of the irradiation, respectively, after 3 d, 1 week, half a month, 1,2,3,4,5 months electrophysiological monitoring. Results The 10 Gy group had electrophysiological changes within 1 week after Gamma Knife irradiation. This change recovered after half a month and gradually recovered with time. In the group of more than 11 Gy, there was an abnormal change of irreversible electrophysiology after Gamma Knife irradiation, and the change aggravated with the extension of time. Conclusions 10 Gy can cause reversible changes in electrophysiology of optic nerve of oppressed cats. 11 Gy can cause irreversible radioactive injury of optic nerve.