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目的:探讨CD44蛋白与胃癌细胞的关系。方法:应用流式细胞术测定胃癌组织CD44阳性细胞率和平均荧光强度。结果:在胃癌组织中,CD44细胞的阳性率为93.46±3.13%,明显高于其在正常组织的比率21.27±9.59%(P<0.01);胃癌组织中CD44蛋白阳性细胞平均荧光强度为175.58±49.21,和正常组织细胞CD44蛋白阳性细胞的141.02±113.44无差别(P>0.05)。结论:胃癌组织中,CD44蛋白增多表明其在胃癌的发生、发展和转移中可能发挥重要作用。
Objective: To investigate the relationship between CD44 protein and gastric cancer cells. Methods: Flow cytometry was used to determine the rate of CD44 positive cells and the average fluorescence intensity of gastric cancer. Results: In gastric cancer tissues, the positive rate of CD44 cells was 93.46±3.13%, which was significantly higher than that of normal tissues (21.27±9.59%, P<0.01). The average fluorescence intensity of CD44 protein positive cells in gastric cancer tissues was 175.58± At 49.21, there was no difference between normal cells and CD44 positive cells at 141.02±113.44 (P>0.05). Conclusion: The increase of CD44 protein in gastric cancer suggests that it may play an important role in the occurrence, development and metastasis of gastric cancer.