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[目的]探讨皮质肌动蛋白(Cortactin)在浸润性乳腺癌组织中的表达及临床意义。[方法 ]通过免疫组化En Vision法检测Cortactin在120例浸润性乳腺癌组织和20例癌旁组织中的表达情况,分析浸润性乳腺癌组织中Cortactin的表达与临床病理学参数的关系。[结果]Cortactin在浸润性乳腺癌组织中的阳性表达率为68.3%(82/120),显著高于癌旁组织15.0%(3/20)。Cortactin表达与乳腺癌病理分级、淋巴结转移、TNM分期、ER、PR及Her-2表达有关(P<0.05)。[结论]Cortactin可能参与乳腺癌的发生、发展,为乳腺癌的治疗提供新的靶点。
[Objective] To investigate the expression of cortactin in invasive breast cancer and its clinical significance. [Method] The expression of Cortactin in 120 invasive breast cancer tissues and 20 paracancerous tissues was detected by immunohistochemical En Vision method. The relationship between the expression of Cortactin and clinicopathological parameters in invasive breast cancer was analyzed. [Results] The positive rate of Cortactin in invasive breast cancer was 68.3% (82/120), which was significantly higher than that in paracancerous tissues (15.0%, 3/20). Cortactin expression was correlated with histological grade, lymph node metastasis, TNM stage, ER, PR and Her-2 expression in breast cancer (P <0.05). [Conclusion] Cortactin may participate in the occurrence and development of breast cancer and provide a new target for the treatment of breast cancer.