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幽门螺杆菌（Hp）与慢性活动性胃炎、消化性溃疡、胃癌以及胃淋巴瘤的发展关系密切。近年来，HP的细胞毒素在其致病性中的地位越来越受到人们的重视。Hp毒素主要有两种，一种是分子量大约为90KDa的空泡毒素（VacA）[1-3]（关于空泡毒素的分子量，不同的作者报道的差异较大，有8
Helicobacter pylori (Hp) is closely related to the development of chronic active gastritis, peptic ulcer, gastric cancer and gastric lymphoma. In recent years, HP’s cytotoxicity in its pathogenicity in the status of more and more people’s attention. There are mainly two kinds of Hp toxins, one is vacuolar toxin (VacA) with a molecular weight of about 90 kDa [1-3]. (Regarding the molecular weight of vacuolar toxins, different authors have reported a large difference of 8