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本文采用竞争性酶联免疫分析和二步生化比色法测定了６７例肝硬化（ＬＣ）患者、４６例健康人血浆Ｐ物质和一氧化氮（ＮＯ）水平，以及血动力学参数。显示失代偿期ＬＣ患者血浆Ｐ物质、ＮＯ水平较代偿期及正常人为高。失代偿期ＬＣ患者全身血管阻力（ＳＶＲ）、平均动脉压（ＭＡＰ）明显降低，心输出量（ＣＯ）明显增加；ＳVＲ与血浆Ｐ物质、ＮＯ水平呈负相关。提示ＮＯ过度形成和释放是启动和维持ＬＣ门脉高动力循环的重要因素。Ｐ物质对维持门脉高压高动力循环起重要作用。
In this study, 67 patients with cirrhosis (LC) and 46 healthy subjects were measured for plasma P and nitric oxide (NO) levels and hemodynamic parameters using competitive enzyme-linked immunosorbent assay and two-step biochemical colorimetric assay. Plasma in patients with decompensated LC showed substance P, NO levels were higher than those in compensated and normal subjects. Systemic vascular resistance (SVR), mean arterial pressure (MAP), and cardiac output (CO) were significantly increased in decompensated LC patients. SVR was negatively correlated with plasma P and NO levels. Suggesting that excessive NO formation and release is an important factor in initiating and maintaining the hyperchronicity of portal hypertension. Substance P plays an important role in maintaining portal hyperdynamic circulation.