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目的:探讨PTEN、cyclinE在绝经前妇女子宫内膜息肉中表达情况并分析其相关性。方法:入选2009年12月~2012年7月在我就诊的子宫内膜息肉患者72例作为观察组,并入选同期在我院进行体检的绝经前妇女73例作为对照组,比较两组人群子宫内膜PTEN、cyclinE表达情况,并分析二者之间的相关性。结果:对照组患者PTEN、cyclinE阳性表达率分别为50.7%、19.2%与观察组患者26.4%、65.3%相比,差异均具有显著的统计学意义(R<0.05)。分析显示,子宫内膜息肉患者中PTEN、cyclinE表达存在明显的负相关,r=-0.423(R<0.05)。结论:绝经前妇女子宫内膜息肉患者中cyclinE表达明显增加,PTEN表达显著减少,二者存在显著的负相关。
Objective: To investigate the expression of PTEN and cyclinE in premenopausal women with endometrial polyps and analyze their correlation. Methods: Seventy-two patients with endometrial polyps who were treated in our hospital from December 2009 to July 2012 were selected as the observation group and 73 premenopausal women who underwent physical examinations during the same period were selected as the control group. The uterus of the two groups were compared Endometrial PTEN, cyclinE expression, and analyze the correlation between the two. Results: The positive rates of PTEN and cyclinE in control group were 50.7% and 19.2%, respectively, which were significantly different from those in observation group (26.4%, 65.3%) (P <0.05). Analysis showed that endometrial polyps in patients with PTEN, cyclinE expression was significantly negative correlation, r = -0.423 (R <0.05). CONCLUSIONS: The expression of cyclinE in premenopausal women with endometrial polyps was significantly increased, while the expression of PTEN was significantly decreased. There was a significant negative correlation between them.