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将小鼠置通有96%N_2、4%O_2混合气的缺氧罐中,动物在72秒钟左右死亡。缺氧前30分钟腹腔注射慢心律6.25～50mg kg 或苯妥英钠12.5～100mg kg 能明显延长缺氧小鼠的存活时间,在一定范围内存在着剂量与效应关系。采用小鼠断头法引起脑缺血30秒后脑组织乳酸含量明显升高。慢心律及苯妥英钠可明显降低小鼠脑缺血后的乳酸升高。这说明慢心律和苯妥英钠对小鼠脑缺血及缺氧有一定的保护作用。
The mice were sacrificed in anoxic tanks containing 96% N 2, 4% O 2 gas mixture and the animals died in about 72 seconds. 30 minutes before anoxia, slow-acting 6.25-50 mg kg or phenytoin 12.5-100 mg kg can significantly prolong the survival time of hypoxic mice, and there is a dose-response relationship within a certain range. The brain tissue was significantly increased in lactic acid content after 30 seconds of cerebral ischemia. Slow heart rhythm and phenytoin sodium can significantly reduce the mice after cerebral ischemia increased lactate. This shows that slow heartbeat and phenytoin sodium in mice with cerebral ischemia and hypoxia have a protective effect.