论文部分内容阅读
目的 研究Dickkopf-4(DKK-4)血清蛋白在卵巢癌中的表达及意义.方法 收集2015年1月至2016年6月在中国医科大学附属盛京医院40例卵巢浆液性乳头状癌和40例正常自愿者血清.采用ELISA的方法检测DKK-4血清蛋白的表达情况,分析其与各临床病理参数的关系.结果 DKK-4蛋白在人卵巢浆液性乳头癌患者血清中的表达含量明显高于正常自愿者血清,其表达含量与卵巢浆液性乳头癌细胞分化程度明显呈正相关.结论 DKK-4蛋白可能参与卵巢浆液性乳头癌发病机制.“,”Objective To detect the expression and significance of Dickkopf-4 in human serous papillary ovarian adenocarcinoma.Method We used ELISA method to detect the expression of DKK-4 protein in 40 malignant tumors serum samples,40 benign tumors serum samples and 40 normal serum samples from January 2015 to June 2016 in the Department of Obstetrics and Gynecology,Shengjing Hospital,China Medical University.The correlation of DKK-4 with clinical-pathological parameters was analized.Results The expression level of DKK-4 protein in serum was increased in serous papillary ovarian adenocarcinoma than in normal control group,and positively associated with cell differentiation degree of adenocarcinoma cells.Conclusion DKK-4 might be involved in the pathogenesis of ovarian epithelial carcinomas.