一般人群尿中8-羟基脱氧鸟苷水平及其影响因素

来源 :环境与职业医学 | 被引量 : 0次 | 上传用户:wuheguo99
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[目的]探讨一般人群尿8-羟基脱氧鸟苷(8-OHd G)水平,以及可能影响因素的作用。[方法]选择华东某市的城市居民共257名作为研究对象,采用超高效液相色谱-串联质谱方法测定尿中8-OHd G水平,高效液相色谱法检测尿中肌酐的浓度,校正尿中的8-OHd G的浓度。影响因素分析采用多重线性回归分析,交互作用采用多因素方差分析模型分析。[结果]该地区一般人群尿中的8-OHd G的质量浓度M(P25~P75)为1.50(0.39~2.24)μg/L,肌酐校正后M(P25~P75)为129.82(50.79~235.58)μg/mol。经吸烟、饮酒情况和体质指数(BMI)分层后,没有发现吸烟、饮酒和BMI单独对尿中8-OHd G改变的影响。多重线性回归分析结果显示,在排除其他混杂因素的影响后,饮酒对尿中8-OHd G水平有影响(P=0.040)。进一步分析发现超重人群中随年龄升高8-OHd G水平有升高趋势(Ptrend<0.05)。[结论]年龄与BMI的交互作用是尿中8-OHd G水平的重要影响因素,尤其是高年龄的超重者更易发生DNA氧化损伤。 [Objective] To investigate the level of urinary 8-OHdG (8-OHdG) in general population and the possible influencing factors. [Method] A total of 257 urban residents from a city of East China were selected as experimental subjects. The levels of 8-OHd G in urine were determined by ultra performance liquid chromatography-tandem mass spectrometry. The urinary creatinine concentrations were measured by high performance liquid chromatography In the concentration of 8-OHd G. Multiple linear regression analysis was used to analyze the influential factors, and multivariate analysis of variance (ANOVA) was used to analyze the interaction. [Results] The urine concentration of 8-OHd G in urine of the general population was 1.50 (0.39-2.24) μg / L, P (P25-P75) was 129.82 (50.79-235.58) μg / mol. After stratified by smoking, alcohol consumption, and body mass index (BMI), no effect of smoking, drinking, and BMI alone on urinary 8-OHd G changes was found. Multiple linear regression analysis showed that alcohol consumption had an effect on the level of 8-OHd G in urine (P = 0.040) after excluding the effects of other confounding factors. Further analysis found that overweight people with increasing age 8-OHd G levels have increased (Ptrend <0.05). [Conclusion] The interaction between age and BMI is an important factor affecting the level of 8-OHd G in urine. Especially in those with overweight, the oxidative DNA damage is more likely.
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