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本研究用含赖型强毒钩体单一蛋白ＯｍｐＬ３９的基因疫苗免疫豚鼠，观察ＯｍｐＬ３９的免疫保护力以及在免疫应答期影响体液免疫的单胺类神经递质５ＨＴ及其ＮＥ、ＤＡ、５ＨＩＡＡ的改变。结果表明，ＯｍｐＬ３９基因疫苗在豚鼠体内能产生较强的阳性抗体，对豚鼠有较强的免疫保护作用。同时发现ＯｍｐＬ３９疫苗在免疫应答期对５ＨＴ以及５ＨＩＡＡ、ＮＥ、ＤＡ有明显影响，其中５ＨＴ、ＤＡ、ＮＥ明显降低，５ＨＩＡＡ明显升高，与空白对照组有显著差异（ｐ＜００５）。提示，ＯｍｐＬ３９疫苗在免疫应答期能刺激机体产生较强的体液免疫功能，对神经系统有明显的调节作用，在炎症的吸收和保护内脏各器官组织等方面起到了积极的作用。
In this study, guinea pigs were immunized with a gene vaccine containing a single protein OmpL39, and the protective effect of OmpL39 and the monoamine neurotransmitter 5HT and its NE, DA, 5 HIAA changes. The results showed that OmpL39 gene vaccine can produce strong positive antibodies in guinea pigs, and has strong immunoprotection against guinea pigs. Also found OmpL39 vaccine in the immune response of 5 HT and 5 HIAA, NE, DA had a significant effect, including 5 HT, DA, NE was significantly lower 5 HIAA was significantly higher than the blank control group were significantly different p <005). These results suggest that OmpL39 vaccine can stimulate the body to produce strong humoral immunity in the immune response period and has a significant regulatory effect on the nervous system and plays an active role in inflammation absorption and organ organ protection.