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背景 儿童发生自身免疫性溶血性贫血病(AIHA)虽然很少见,但常与新近发生的感染合并发生。已有数例报道认为接种白喉—百日咳—破伤风(DPT)疫苗会并发AIHA。研究设计和方法 一例出生后6星期婴儿在接种DPT疫苗5天后被诊断为有生命危险的AIHA。患者必须在3个星期中每天输血和/或血液置换。发现MK纯合子RBC与患者的自身抗体相容。为维持患者的Hb水平,必须输注MK纯合子RBC以及稍后输注一名不同血型糖蛋白Mi Ⅶ供者RBC,直至自身抗体消失,自身抗体
Background Children with autoimmune hemolytic anemia (AIHA), although rare, often develop with newly acquired infections. Several reports have reported that vaccination with diphtheria-pertussis-tetanus (DPT) vaccines can be complicated by AIHA. Study Design and Method One example Six weeks after birth an infant is diagnosed with life-threatening AIHA 5 days after inoculation of the DPT vaccine. Patients must have blood transfusions and / or blood transfusions every 3 weeks. MK homozygous RBC was found to be compatible with the patient’s autoantibodies. In order to maintain Hb levels in patients, MK homozygous RBC must be infused and later a different glycoprotein Mi Ⅶ donor RBC must be infused until autoantibodies disappear. Autoantibodies