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已知最后区（ａｒｅａｐｏｓｔｒｅｍａ，ＡＰ）存在血管紧张素Ⅱ（ＡⅡ）受体，并可感受血中ＡⅡ水平的变化。本文采用微量注射ＡⅡ于ＡＰ的方法，观察了ＡＰ和肾功能的关系。结果：ＡＰ内微量注射ＡⅡ（２，２０ｎｇ）引起肾小球滤过率（ＧＦＲ），肾血浆流量（ＲＰＦ），尿钠排泄（ＵＮａＶ）的增加（Ｐ＜０．０５）。该作用可被ＡＰ内微量注射ＡⅡ拮抗剂ｓａｒａｌａｓｉｎ或切断肾神经所阻断（Ｐ＜０．０５）。而静脉注射ｓａｒａｌａｓｉｎ却不能阻断该作用。微量注射ＡⅡ于孤束核后ＧＦＲ，ＲＰＦ，ＵＮａＶ无变化（Ｐ＞０．０５）。上述结果表明ＡⅡ诱导肾血流动力学和尿钠的排泄改变可能是通过ＡＰ的。
It is known that there are angiotensin Ⅱ (AⅡ) receptors in areapostrema (AP), and the changes of AⅡ level in blood can be felt. In this paper, micro-injection of A Ⅱ in the AP method to observe the relationship between AP and renal function. Results: Microinjection of A Ⅱ (2,20ng) into AP caused an increase of GFR, RPF and UNaV (P <0.05). This effect could be blocked by microinjection of AII antagonist saralasin into the AP or by cutting off the renal nerves (P <0.05). Intravenous injection of saralasin did not block this effect. Microinjection of AⅡ showed no change in GFR, RPF and UNaV after solitary nucleus (P> 0.05). These results suggest that AII-induced changes in renal hemodynamics and urinary sodium excretion may be through the AP.