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肿瘤细胞中糖酵解途径的增强主要是由于氧化磷酸化功能不可逆转的损伤所导致的(Warburg效应),不同类型的肿瘤细胞中导致氧化磷酸化代谢途径损伤的机制以及主要依赖的能量代谢途径(糖酵解和氧化磷酸化)各不相同,应通过大量实验研究来进一步评价不同类型肿瘤细胞中线粒体的氧化磷酸化能力。在本文中综述了近年来关于各种不同类型肿瘤细胞中导致氧化磷酸化代谢途径受损的可能机制的研究新进展,以期为进一步研究线粒体氧化磷酸化代谢途径受损在致癌进程中可能发挥的作用提供参考资料。
The enhancement of glycolytic pathways in tumor cells is mainly due to the irreversible damage of oxidative phosphorylation (Warburg effect), the mechanism leading to oxidative phosphorylation metabolic pathways in different types of tumor cells and the mainly dependent energy metabolism pathways (Glycolytic and oxidative phosphorylation) vary widely, a large number of experimental studies should be conducted to further evaluate the mitochondrial oxidative phosphorylation capacity in different types of tumor cells. In this review, we review the recent advances in the possible mechanisms that lead to the impaired oxidative phosphorylation of various types of tumor cells in order to further investigate the possible mitochondrial oxidative phosphorylation pathway that may play an important role in carcinogenesis Function to provide reference materials.