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白三烯是近几年从白细胞及其它组织中发现的一类新的具有高度生物活性的花生四烯酸衍生物,与支气管哮喘、心绞痛、心肌梗塞、急慢性炎症以及变态反应等许多疾病的发生发展都有密切关系,同时许多具有抗炎、抑制免疫反应的药物(如阿斯匹林、糖皮质激素等)作用机制也与白三烯有关。因此,对白三烯及其对抗剂的研究具有较大的理论意义及实用价值。一、白三烯命名与来源(一)命名白三烯最早是从家兔白细胞,如多核白细胞、嗜碱性白细胞及单核巨噬细胞等分离而得,其分子结构中含三个偶联双键,故命名为白三烯(Leukotrienes,LTs)。
Leukotriene is a new class of highly bioactive arachidonic acid derivatives found in white blood cells and other tissues in recent years. It is associated with many diseases such as bronchial asthma, angina pectoris, myocardial infarction, acute and chronic inflammation and allergy Development and development are closely related to the same time, many anti-inflammatory and immune suppression drugs (such as aspirin, glucocorticoids, etc.) mechanism of action is also related to leukotrienes. Therefore, the study of leukotrienes and their antagonists has great theoretical significance and practical value. First, the name and source of leukotriene (A) Name Leukotriene was first isolated from rabbit white blood cells, such as polymorphonuclear leukocytes, basophils and monocytes and other macrophages derived from its molecular structure containing three coupling Double bond, so named leukotrienes (Leukotrienes, LTs).