论文部分内容阅读
目的:探讨益气化湿胶囊对腺嘌呤诱导大鼠高尿酸血症、肾损伤的防治作用。方法:利用腺嘌呤灌胃法诱导Wistar大鼠制备高尿酸血症和肾损伤模型,益气化湿胶囊预防治疗3周,测定与高尿酸血症和肾衰相关的各项组织器官和血液生化指标。结果:益气化湿胶囊可显著降低血清尿酸水平,与别嘌呤醇的降尿酸效果相当;并能显著降低尿酸氮、肌酐、丙二醛水平。结论:益气化湿胶囊有干预腺嘌呤诱导高尿酸血症和肾损伤的作用。
Objective: To investigate the preventive and therapeutic effects of Yiqi Huashi Capsule on adenine-induced hyperuricemia and renal injury in rats. Methods: The model of hyperuricemia and renal injury induced by adenine gavage was induced in Wistar rats. Yiqi Huashi Capsule was prophylactically treated for 3 weeks. The tissues, organs and blood biochemistry of hyperuricemia and renal failure index. Results: Yiqi Huashi Capsule can significantly reduce serum uric acid levels, and uric acid allopurinol equivalent effect; and can significantly reduce uric acid, creatinine, malondialdehyde levels. Conclusion: Yiqi Huashi Capsule has the effect of intervention of adenine to induce hyperuricemia and renal injury.