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方法 :应用放射免疫方法对 2 6例肺癌 (观察组 )和 2 0例肺良性疾病 (对照组 )患者的支气管肺泡灌洗液和血清中降钙素、β2 —微球蛋白和癌胚抗原的含量进行了测定。结果表明 :1在血清中肺癌组仅降钙素高于对照组 (P<0 .0 1) ;2在支气管肺泡灌洗液中肺癌组所有三项肿瘤标志物均比对照组明显升高 (P<0 .0 1) ;3取对照组 95 %的可信限即 x+1.96 Sx为各项指标的阳性界值 ,在支气管肺泡灌洗液中降钙素、β2 —微球蛋白和癌胚抗原对肺癌的阳性率分别为 92 .3%、80 .7%和 88.6 %。提示支气管肺泡灌洗液中肿瘤标志物的测定对早期和周围型肺癌的诊断有一定的意义 ,其临床价值优于血清。
Methods: Radiofrequencyimmunoassay (RIA) was used to detect the expression of calcitonin, β2 - microglobulin and carcinoembryonic antigen in 26 patients with lung cancer (observation group) and 20 patients with benign lung disease (control group) Content was measured. The results showed that: 1 in the serum of lung cancer group only calcitonin higher than the control group (P <0.01); 2 in bronchoalveolar lavage lung cancer group all three tumor markers were significantly higher than the control group P <0.01) .3 The 95% confidence limit of the control group, x + 1.96 Sx, is the positive cutoff for each indicator. Calcitonin, β2-microglobulin and cancer in bronchoalveolar lavage fluid The positive rates of embryo antigen to lung cancer were 92.3%, 80.7% and 88.6% respectively. It is indicated that the determination of tumor markers in bronchoalveolar lavage fluid has certain significance for the diagnosis of early and peripheral lung cancer, and its clinical value is superior to that of serum.