1临床资料患者女,28岁,右侧乳房下方褐色斑块4年,扩大半年。患者4年前发现右侧乳房内下方皱褶处淡褐色斑块,初为绿豆大小,稍有隆起,无自觉症状,未予治疗。近半年来,皮损逐渐扩大,且颜色逐渐加深(图1),遂来本院门诊就诊。患者既往体健,家族成员无类似疾病。体格检查:系统检查未见明显异常,皮肤科情况:右侧乳房内下方皱褶处可见一黄豆大小的褐色斑块,边界不清,表面凹凸不平,质韧,无触痛。该患者的治疗方 1 Clinical data Female patient, 28 years old, brown plaque on the right side of the breast for 4 years, expanding for six months. Patient 4 years ago found within the lower right breast folds at the Department of brown patches, the size of the first green beans, a little bulge, no symptoms, no treatment. The past six months, the gradual expansion of lesions, and gradually deepened the color (Figure 1), then came to our hospital clinic. Past patient health, family members no similar diseases. Physical examination: no obvious abnormalities were found in the system examination. Dermatology: A brownish-brown patch of brown beans was seen at the lower folds of the right breast. The border was unclear. The surface was rugged, tough and tender. The patient’s treatment