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目的探讨孕母患自身免疫性甲状腺疾病对婴儿甲状腺功能的影响。方法通过浙江省新生儿疾病筛查网络系统,从2001年7月～2003年6月对78例母亲患自身免疫性甲状腺疾病的婴儿甲状腺功能进行追踪观察,采用病例对照分析的方法对可能影响婴儿甲状腺功能的因素进行非条件logistic回归分析。结果(1)78例孕母患自身免疫性甲状腺疾病的婴儿,其甲状腺功能正常37例,先天性甲低7例,甲亢1例,高TSH血症33例,与同期健康母亲的婴儿相比差异有显著性。(2)经多因素非条件logistic回归分析筛选出孕期母亲甲状腺功能状态、孕母患自身免疫性甲状腺疾病的种类、婴儿体内TSH受体抗体(TRAb)与婴儿甲状腺功能异常有关(均P<0.05)。结论孕母患自身免疫性甲状腺疾病对婴儿甲状腺功能有影响。为减少婴儿甲状腺功能异常的发生率,必须加强孕母妊娠期甲状腺功能的监测。
Objective To investigate the effect of autoimmune thyroid disease on the thyroid function in infants. Methods From July 2001 to June 2003, 78 cases of thyroid function in mothers with autoimmune thyroid disease were followed up through the Zhejiang Neonatal Disease Screening Network System. Case-control analysis was used to evaluate the effect of thyroid function in infants Thyroid function factors were analyzed by unconditional logistic regression. Results (1) 78 cases of pregnant women with autoimmune thyroid disease in 37 cases of normal thyroid function, congenital hypothyroidism in 7 cases, hyperthyroidism in 1 case, high TSH hyperlipidemia in 33 cases, compared with the same period of healthy mothers of infants The difference was significant. (2) Multivariate non-conditional logistic regression analysis screened out the status of thyroid function during pregnancy, the type of autoimmune thyroid disease in pregnant women, the TSA receptor antibody (TRAb) in infants was related to abnormal thyroid function in infants (all P <0.05 ). Conclusion Pregnant women with autoimmune thyroid disease have an impact on thyroid function in infants. In order to reduce the incidence of abnormal thyroid function in infants, the monitoring of thyroid function during pregnancy should be strengthened.