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目的:探讨静脉应用地尔硫卓艹对心脏电生理的影响。方法:38例阵发性室上性心动过速患者消融成功后的自愿者,静脉给予地尔硫卓艹,首剂0.2m g/kg静脉推注(稀释至10~15m l,5m in内推完),继续以1~5μg(kg.m in)维持滴注,30m in后开始测量相关数值。结果:心率减慢,房室结传导时间及有效不应期延长,心房及心室的有效不应期缩短均有统计学差异,心房内的传导时间(高右房起搏至希氏束A波的时间)及HV的传导时间不受影响,心房内的离散度无明显统计学差异。无一例在试验过程中出现窦性心动过缓、窦性停搏及房室传导阻滞发生。结论:静脉滴注地尔硫卓艹对心率、房室结的影响是有限的,对窦房结和房室结功能正常者应用是安全的。
Objective: To investigate the effect of intravenous diltiazem on cardiac electrophysiology. Methods: Thirty-eight volunteers who had successful ablation of paroxysmal supraventricular tachycardia were infused with diltiazem intravenously. The first dose of 0.2 mg / kg intravenous injection (diluted to 10-15 m l, 5 m in) Continue to 1 ~ 5μg (kg.m in) to maintain the instillation, 30m in later began to measure the relevant values. Results: The heart rate slowed down, atrioventricular nodal conduction time and effective refractory period prolonged, atrial and ventricular effective refractory period shortened were statistically significant, atrial conduction time (right atrial pacing to His bundle A wave Of the time) and HV conduction time is not affected, atrial dispersion no significant difference. No case of sinus bradycardia occurred during the trial, sinus arrest and atrioventricular block occurred. CONCLUSION: Diltiazem intravenous drip has a limited impact on heart rate and atrioventricular node, and is safe for sinus node and atrioventricular node function.