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目的:研究尿激酶型纤溶酶原激活剂(uPA)及其特异受体(uPAR)在舌鳞癌(TSCC)中的表达及其与临床病理参数的关系。方法:应用免疫组化SABC法检测uPA、uPAR在74例TSCC组织和15例癌旁正常黏膜中的表达。Spearman法和Mann-WhitneyU法分析其表达的相关性及与舌鳞癌临床病理参数的关系,χ2检验分析其与颈淋巴结转移的关系。结果:TSCC组织中uPA和uPAR的阳性表达率分别为71.6%和64.8%,且表达呈正相关(P<0.05)。uPA的表达水平与临床分期、颈淋巴结转移相关,与肿瘤病理学分级无关;uPAR与颈淋巴结转移相关,与临床分期、肿瘤病理学分级无关。uPA和uPAR同时阳性表达组,颈淋巴结转移率显著高于同时阴性表达组,两组间比较,差异有非常显著意义(P<0.05)。结论:uPA和uPAR在TSCC中明显高表达,并与TSCC的颈淋巴结转移密切相关。
Objective: To investigate the expression of urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) in tongue squamous cell carcinoma (TSCC) and its relationship with clinicopathological parameters. Methods: Immunohistochemical SABC method was used to detect the expression of uPA and uPAR in 74 cases of TSCC and 15 cases of adjacent normal mucosa. Spearman’s method and Mann-WhitneyU method were used to analyze the correlation between the expression and the clinicopathological parameters of tongue squamous cell carcinoma. The relationship between cervical lymph node metastasis and χ2 test was analyzed. Results: The positive rates of uPA and uPAR in TSCC were 71.6% and 64.8%, respectively, and the expressions were positively correlated (P <0.05). The expression level of uPA was correlated with clinical stage and lymph node metastasis, but not with the grade of tumor pathology. uPAR was correlated with cervical lymph node metastasis, but not with clinical stage and tumor pathological grade. The positive rates of uPA and uPAR in cervical lymph node metastasis were significantly higher than those of negative uPA and uPAR. There was significant difference between the two groups (P <0.05). Conclusion: uPA and uPAR are highly expressed in TSCC and closely related to cervical lymph node metastasis of TSCC.