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目的 :探讨周围神经鞘膜肿瘤 (PNST)中异源性成分的形态特点及组织发生。方法 :收集近 19年间外检材料及会诊病例中伴有异源性成分的PNST 12例 ,应用HE、组化及免疫组化进行染色 ,光镜观察形态变化特点。结果 :①伴有异源性成分的MPNST为 10 1% ;②在 12例这类肿瘤中 ,伴有横纹肌肉瘤成分者 3例、良性骨组织 2例、软骨肉瘤成分 1例、腺性成分 2例、黑色素 2例 ,另外 1例I型神经纤维瘤病者 ,瘤组织内可同时见到黑色素细胞及粘液腺。结论 :PNST中出现异源性成分并不少见 ,它的形成可能与其起源细胞具有多向分化潜能有关。
Objective: To investigate the morphological characteristics and histogenesis of heterologous components in peripheral nerve sheath tumor (PNST). Methods: 12 cases of PNST with heterologous components in the materials and consultation cases collected during the past 19 years were collected and stained with HE, histochemistry and immunohistochemistry. Morphological changes were observed with light microscope. Results ① The MPNST with heterologous components was 10 1%. ② Of the 12 tumors, there were 3 cases with rhabdomyosarcoma, 2 cases with benign bone, 1 case with chondrosarcoma and 2 cases with glandular component 2 For example, 2 cases of melanin, another case of type I neurofibromatosis, melanoma cells and mucus glands can be seen both in the tumor tissue. CONCLUSION: It is not uncommon to find heterologous components in PNST. Its formation may be related to the multidirectional differentiation potential of its origin cells.