本文报告了一起较为少见的梅毒家庭聚集感染的调查：２２岁男性青年因有冶游史而感染梅毒（潜伏）后传给配偶，继而母亲通过胎盘传播给其子女，致使一家四人全部感染。患儿最初曾被误诊为“牛皮癣”“传染性肝炎”等而被延误治疗。因此，对难以诊断的新生儿皮损、肝脾肿大，应尽早做梅毒的血清学检查，以便明确诊断，及时给予正确的治疗。 This article reports a relatively rare survey of syphilis in families: a 22-year-old male who was infected with syphilis (latent) due to a history of etiquette and passed on to his spouse who then transmitted through the placenta to his children resulted in a total infection of 4 persons. Children were initially misdiagnosed as “psoriasis” “infectious hepatitis” and were delayed treatment. Therefore, difficult to diagnose neonatal lesions, hepatosplenomegaly, syphilis serology should be done as soon as possible in order to confirm the diagnosis, timely and correct treatment.