目的　探讨泌尿男生殖系多原发恶性肿瘤的发病率及预后。　方法　回顾性分析近 8年收治的 2 2例多原发恶性肿瘤的发病率、第 1及第 2恶性肿瘤间隔时间及预后。　结果　泌尿男生殖系多原发恶性肿瘤占同期收治的泌尿男生殖系恶性肿瘤的 3 .2 % ,7例同时发病者存活时间平均 15个月 ;异时发生 15例中 3例存活 7个月～ 5年 ,12例在第 2癌治疗后 8个月至 15年仍存活。　结论　泌尿男生殖系多原发恶性肿瘤近年有增加趋势 ,第 1癌治疗后应密切随访 ,及早发现和正确治疗第 2原发癌是延长生存期的关键 Objective To investigate the incidence and prognosis of multiple primary malignant tumors in urinary male reproductive system. Methods The incidence of multiple malignant tumors in the past 8 years and the interval and prognosis of malignant tumors in the first and second years were retrospectively analyzed. Results The urinary male reproductive tract multiple primary malignant tumors accounted for 3.2% of the male patients with genitourinary malignancies admitted in the same period. The mean survival time of the seven patients with concurrent disease was 15 months. Three of the 15 cases of heterotopia survived for 7 months ~ 5 years and 12 survived 8 months to 15 years after the second cancer treatment. Conclusions The multiple primary malignant tumors of urinary male reproductive system have been increasing in recent years. The treatment of the first cancer should be closely followed up. The early detection and correct treatment of the second primary cancer is the key to prolong survival