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目的 :探讨健脾益气化湿中药及西药对慢性萎缩性胃炎 (CAG)患者表皮生长因子 (EGF)水平的影响。方法 :经中医辨证论治分为健脾 1组、健脾 2组、化湿组、西药组和正常对照组 (简称对照组 ) ,并进行相应的治疗 ,检测各组治疗前后血清EGF水平变化 ,并作疗效对比分析。结果 :CAG各组治疗前血清EGF均明显高于对照组 (P <0 0 1) ,治疗后健脾 1、2组临床症状和病理变化明显改善 (P <0 0 1) ,两健脾组血清EGF含量也明显下降 (P <0 0 5) ,化湿组治疗后血清EGF上升 (P <0 0 5) ,西药组治疗后血清EGF变化不大。结论 :CAG炎症刺激可导致血清EGF反应性升高 ,经中药治疗后EGF水平回复 ;检测EGF可作为CAG转归观察的敏感指标
Objective : To investigate the effects of Jianpi Yiqi Humidifying Chinese Medicine and Western medicine on the level of epidermal growth factor (EGF) in patients with chronic atrophic gastritis (CAG). Methods: TCM syndrome differentiation was divided into spleen 1 group, Jianpi 2 group, Huashi group, western medicine group and normal control group (abbreviated as control group), and corresponding treatment was performed to detect changes of serum EGF levels before and after treatment in each group. For comparative analysis of efficacy. RESULTS: Before treatment, serum EGF of CAG groups was significantly higher than that of control group (P < 0.01). After treatment, the clinical symptoms and pathological changes of spleen 1 and 2 groups were significantly improved (P <0 01). Serum EGF levels also decreased significantly (P < 0.05), EGF increased after treatment (P <0.05), serum EGF did not change significantly after treatment. Conclusion :CAG inflammatory stimuli can lead to increased serum EGF reactivity. EGF levels can be restored after treatment with traditional Chinese medicine. Detection of EGF can be used as a sensitive index for observation of CAG outcomes.