急性肾衰伴有严重少尿时,至少有二个需要考虑的因素:一是治疗剂本身的作用;另一是用药的当时存在的生理情况或病理生理情况。有下列几个例子:第一是应用碳酸氢钠预防甲氧喋呤的沉淀。在这情况中,药物的作用依赖肾小球滤液沿肾单位向下运行而成为肾小管液时使之碱化。如果管腔内的沉淀是由先前已沉淀的甲氧喋呤所造成,那就没有什么办法可使 Acute renal failure with severe oliguria, there are at least two factors to consider: First, the role of the therapeutic agent itself; the other is the existence of the physiological conditions or pathophysiological conditions. The following examples: The first is the use of sodium bicarbonate to prevent the precipitation of methotrexate. In this case, the effect of the drug relies on basification of the glomerular filtrate as it runs down the nephron and becomes tubular fluid. If the lumen is precipitated by previously precipitated methotrexate, then there is no way to make it