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目的探讨人乳头状瘤病毒(HPV)感染与宫颈癌发病关系,为临床预防宫颈癌提供参考依据。方法选取医院2012年1月-2014年12月50例行宫颈癌活检或宫颈癌根治术患者宫颈癌组织标本作为研究组,50例子宫肌瘤切除术患者的宫颈组织标本作为对照组,采取免疫组织化学染色法测定两标本中HPV感染情况,并分析HPV感染与宫颈癌临床特征的相互关系,研究数据均采取SPSS19.0统计软件进行处理。结果研究组中HPV感染率46.0%,明显高于对照组的4.0%,两组数据比较差异有统计学意义(P<0.05);通过对HPV感染与宫颈癌临床特征的相互关系分析,未闭经患者中HPV感染率66.7%,明显高于闭经患者的15.0%;临床Ⅱ期患者中HPV感染率87.5%,明显高于Ⅰ期患者的26.5%;淋巴结转移患者中HPV感染率83.3%,明显高于淋巴结无转移患者的25.0%;病理学组织分级3级患者中HPV感染率80.0%,明显高于病理学组织分级1、2级的30.0%、40.0%,以上差异均有统计学意义(P<0.05)。结论 HPV在宫颈癌中具有较高的感染率,且HPV感染与宫颈癌的发病有着密切的联系。
Objective To investigate the relationship between human papillomavirus (HPV) infection and cervical cancer and to provide a reference for clinical prevention of cervical cancer. Methods From January 2012 to December 2014, 50 cases of cervical cancer tissue from patients undergoing cervical biopsy or radical resection of cervix cancer were selected as the study group, and 50 cases of cervical myomectomy patients as the control group, Histochemical staining was used to determine the HPV infection in two specimens. The correlation between HPV infection and the clinical features of cervical cancer was analyzed. The data were processed by SPSS19.0 statistical software. Results The HPV infection rate in study group was 46.0%, which was significantly higher than that in control group (4.0%). There was significant difference between the two groups (P <0.05). According to the correlation between HPV infection and clinical features of cervical cancer, The HPV infection rate in patients was 66.7%, which was significantly higher than that in amenorrhea patients (15.0%). The HPV infection rate in clinical stage Ⅱ patients was 87.5%, which was significantly higher than that in stage Ⅰ patients (26.5%). The HPV infection rate in patients with lymph node metastasis was 83.3% The incidence of HPV infection was 80.0% in pathological grade 3 patients, which was significantly higher than 30.0% and 40.0% in grade 1 and grade 2 of pathological tissues, all of which were statistically significant (P <0.05). Conclusion HPV in cervical cancer has a high infection rate, and HPV infection and cervical cancer are closely linked.