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高胰岛素血症是新生儿期持继性低血糖的常见原因之一。如不及时的诊断与治疗,可造成不可逆的脑损伤。此病常有弥漫性的胰腺损伤,称之为“胰岛细胞成熟障碍综合症”(islet call olysm-aturation)。病理表现为小腺瘤,胰岛细胞瘤及胰岛细胞的发育障碍与胰岛母细胞的增殖。作者几例所切除的胰腺组织学检查都有胰岛细胞增殖。即胰管分泌腺产生的胰岛细胞数增多。其机能表现为微小腺瘤的自主功能与基本荷尔蒙分泌调节的异常。由胰管产生的B细胞数量及大小均增加,而且为多形性,可成簇成单个的分散在外分泌组织中,另外可发现胰岛细胞的解体,有些病
Hyperinsulinemia is one of the common causes of persistent hypoglycemia during the neonatal period. If not diagnosed and treated in time, it can cause irreversible brain damage. The disease often has diffuse pancreatic damage called “islet call olysm-aturation.” Pathological manifestations are small adenomas, islet cell tumors, and islet cell developmental disorders and islet cell proliferation. Several cases of pancreatic histological examination of the pancreas showed proliferation of islet cells. That is, the number of pancreatic islet cells produced by pancreatic duct secretory glands increases. Its function is manifested in the abnormal function of the adenomas and the regulation of basic hormone secretion. The number and size of B cells produced by pancreatic ducts increase, and they are pleomorphic. They can be clustered and dispersed into exocrine tissues. In addition, the disintegration of islet cells can be found.