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目的探讨联用复方丹参滴丸与硝酸异山梨酯治疗冠状动脉粥样硬化性心脏病(冠心病)心绞痛的临床疗效及对心功能的影响。方法以临床症状、体表心电图、等方法,观察单用硝酸异山梨酯及复方丹参滴丸与硝酸异山梨酯联用治疗冠心病心绞痛的疗效及其对心功能影响。结果①硝酸异山梨酯与复方丹参滴丸,两药合用的临床疗效(85.3%)与心电图疗效(75.0%)优于单用硝酸异山梨酯(72.3%和58.3%),差异有统计学意义(P<0.05或P<0.01)。②复方丹参滴丸可改善心绞痛患者血液流变性,增加心肌血供;减慢心率,降低心肌氧耗,以稳定心绞痛。结论复方丹参滴丸对冠心病心绞痛有较好疗效;复方丹参滴丸与硝酸异山梨酯合用更适合血容量不足及对扩血管药物敏感的心绞痛老年患者
Objective To investigate the clinical efficacy of compound Danshen dripping pills and isosorbide dinitrate in the treatment of angina pectoris of coronary atherosclerotic heart disease (CHD) and its influence on cardiac function. Methods Clinical symptoms, body surface electrocardiogram, and other methods were used to observe the effects of isosorbide dinitrate alone and compound danshen dripping pills and isosorbide dinitrate on angina pectoris in patients with coronary heart disease and its influence on cardiac function. Results (1) Isosorbide dinitrate and compound Danshen dripping pills had the best clinical efficacy (85.3%) and electrocardiogram (75.0%) in combination with isosorbide dinitrate (72.3% and 58.3%), the difference was statistically significant (P <0.05 or P <0.01). ② compound Danshen dripping pills can improve the blood rheology of patients with angina and increase blood supply to the heart; slow down the heart rate, reduce myocardial oxygen consumption, to stabilize angina. Conclusion Compound Danshen Dripping Pill has a good curative effect on angina pectoris of coronary heart disease. Compound Danshen Dripping Pill and isosorbide dinitrate are more suitable for angina pectoris patients with hypovolemia and vasodilator drug sensitivity