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目的:评价浙新霉素体外抗真菌活性。方法:采用CLSI推荐的M-38A方案测定浙新霉素对7种皮肤癣菌最小抑菌浓度(MIC)及最小杀菌浓度(MFC)。结果:浙新霉素对7种皮肤癣菌的MIC范围为0.125~2.000μg·ml-1,MFC范围为0.250~4.000μg·ml-1。结论:浙新霉素具有较强的抗真菌活性,能抑制和杀灭絮状表皮癣菌、红色毛癣菌、紫色毛癣菌、犬小孢子菌、须癣毛癣菌、断发毛癣菌、石膏样小孢子菌等多种皮肤癣菌。
Objective: To evaluate the in vitro antimycotic activity of Zhexinomycin. Methods: The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MICs) of ZheNeimomycin against 7 kinds of dermatophytes were determined by CLSI M-38A protocol. Results: The MICs of Zhetromycin against 7 kinds of dermatophytes were 0.125 ~ 2.000μg · ml-1, and the range of MFC was 0.250 ~ 4.000μg · ml-1. Conclusion: Zhejiang neomycin has a strong antifungal activity, can inhibit and kill Epidermophyton floccosum, Trichophyton rubrum, Trichophyton rubrum, Microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum , Plaster-like microsporum and other dermatophytes.