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目的比较芬太尼透皮贴剂与硫酸吗啡缓释片在缓解老年肝癌晚期癌性疼痛的疗效和不良反应。方法137例老年肝癌晚期癌性疼痛患者,随机分为AB两组。A组口服硫酸吗啡缓释片,B组使用芬太尼透皮贴剂,比较缓解老年肝癌晚期癌性疼痛的效果和不良反应。结果两组用药后均有缓解癌性疼痛效果,A组总有效率为82.35%,B组总有效率为97.10%,差异有统计学意义(P<0.01);不良反应方面B组不良反应明显低于A组,差异有统计学意义(P<0.01)。结论芬太尼透皮贴剂在缓解癌性疼痛反面较口服硫酸吗啡缓释片安全方便,疗效确切,不良反应少,是治疗老年肝癌晚期疼痛的理想药物。
Objective To compare the efficacy and adverse reactions of fentanyl transdermal patch and morphine sulfate sustained-release tablets in relieving advanced stage cancer of the elderly with hepatocellular carcinoma. Methods A total of 137 elderly patients with advanced cancer of liver cancer with pain were randomly divided into two groups. A group oral morphine sulfate sustained-release tablets, B group fentanyl transdermal patch, the more effective in the treatment of advanced cancer with advanced cancer of the side effects and adverse reactions. Results The pain relief effect of both groups were relieved after treatment. The total effective rate in group A was 82.35%, the total effective rate in group B was 97.10%, the difference was statistically significant (P <0.01); adverse reactions in group B were obvious Lower than that of A group, the difference was statistically significant (P <0.01). Conclusion Fentanyl transdermal patch in the relief of cancer pain than the oral administration of morphine sulfate sustained-release tablets safe, convenient and effective, less adverse reactions, is an ideal drug for the treatment of advanced liver cancer patients with advanced pain.