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目的通过类风湿关节炎(RA)患者血清中人类软骨糖蛋白-39(HCgp-39)水平的检测,研究其与RA疾病活动的相关性及早期诊断意义。方法采用ELISA法检测患者血清中HCSp-39含量,免疫速率散射比浊法测类风湿因子(RF)、C反应蛋白,共检测51例RA患者,50例非RA患者和30例健康人,并进行比较分析。结果RA患者血清中HCSp-39水平明显高于非RA患者和健康人,且与血沉,C反应蛋白,IgM型类风湿因子水平等活动性指标有关。结论HCgp-39水平与RA疾病活动性相关,监测其浓度变化有助于发现骨关节破坏和疾病的早期诊断。
OBJECTIVE: To investigate the correlation between the level of HCgp-39 and the activity of RA in patients with rheumatoid arthritis (RA) and the significance of its early diagnosis. Methods The levels of HCSp-39 in serum were measured by ELISA, and the rheumatoid factor (RF) and C-reactive protein were detected by the immunostaining nephelometry. A total of 51 RA patients, 50 non-RA patients and 30 healthy controls were detected. For comparative analysis. Results The serum levels of HCSp-39 in patients with RA were significantly higher than those in non-RA patients and healthy subjects, and were related to the activity indexes such as ESR, C-reactive protein and rheumatoid factor IgM. Conclusions The level of HCgp-39 is correlated with the activity of RA disease. Monitoring the changes of the concentration of HCgp-39 may help to find the early diagnosis of bone and joint destruction and disease.