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目的 探讨CD15抗原的表达及含量与胆囊癌的临床病理意义。 方法 应用微波-LSAB免疫组织化学法和图象分析技术,检测45例胆囊癌,17例胆囊腺瘤和10例慢性胆囊炎组织中CD15抗原表达及含量。 结果 CD15抗原表达阳性率及阳性细胞积分A值,在胆囊癌中(71％,4.0±3.2)显著高于胆囊腺瘤(35％,0.9±0.3)和慢性胆囊炎(20％,0.4±0.1)(P<0.05,P<0.01);胆囊癌Ⅱ,Ⅲ级(90％,5.4±1.7)显著高于Ⅰ级(58％,2.2±3.1)(P<0.05,P<0.01);有转移的肿瘤(88％,6.5±3.5)(P<0.05,P<0.01);显著高于无转移的肿瘤(52％,3.3±2.1)(P<0.01)。 结论 CD15抗原表达与胆囊癌的发生、细胞增殖、分化和转移相关,对判断胆囊癌的恶性程度、预测生物学行为和预后具有一定临床意义。
Objective To investigate the expression and content of CD15 antigen and clinicopathological significance of gallbladder carcinoma. Methods Microwave-LSAB immunohistochemistry and image analysis techniques were used to detect the expression and content of CD15 antigen in 45 cases of gallbladder carcinoma, 17 cases of gallbladder adenoma and 10 cases of chronic cholecystitis. Results The positive rate of CD15 antigen expression and positive cell integral A value were significantly higher in gallbladder carcinoma (71%, 4.0±3.2) than in gallbladder adenoma (35%, 0.9±0.3) and chronic cholecystitis (20%, 0.4±0.1). (P <0.05, P <0.01); gallbladder cancer II, grade III (90%, 5.4 ± 1.7) was significantly higher than grade I (58%, 2.2 ± 3.1) (P <0.05, P <0.01); The tumors (88%, 6.5 ± 3.5) (P <0.05, P <0.01) were significantly higher than those without metastasis (52%, 3.3 ± 2.1) (P <0.01). Conclusion The expression of CD15 antigen is associated with the occurrence, proliferation, differentiation and metastasis of gallbladder carcinoma. It has certain clinical significance for judging the malignancy, predicting biological behavior and prognosis of gallbladder carcinoma.