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目的研究淋巴细胞性垂体炎(LyH)的临床特点,为诊断和治疗提供依据。方法对我院内分泌科收治的15例LyH患者临床资料进行回顾性分析。结果患者的发病中位年龄为46岁,男性4例,女性11例。15例LyH患者主要表现为颅内占位、尿崩症和垂体功能减退,单纯眼部表现也应予以重视。LyH采用糖皮质激素治疗1个月后症状改善明显,复查垂体,MRI检查结果显示,9例患者垂体明显缩小,垂体柄变细,垂体储备功能明显改善;4例改善不明显者给予免疫抑制剂治疗。随访1年后,3例复发。结论 LyH临床特征具有多样性、复发性等特点,误诊率高。糖皮质激素治疗能使垂体明显缩小,症状显著改善,垂体功能有所恢复。
Objective To study the clinical features of lymphocytic hypophysitis (LyH) and provide the basis for diagnosis and treatment. Methods The clinical data of 15 cases of LyH treated in Department of Endocrinology of our hospital were retrospectively analyzed. Results The median age of patients was 46 years old, 4 males and 11 females. 15 cases of LyH patients mainly for intracranial space, diabetes insipidus and pituitary dysfunction, simple eye performance should also be taken seriously. LyH with glucocorticoid treatment 1 month after the symptoms improved significantly, review of the pituitary, MRI examination showed that 9 patients significantly reduced pituitary, pituitary stalk thinning, pituitary reserve was significantly improved; 4 cases were not significantly improved immunosuppressive agents treatment. One year after follow-up, three patients relapsed. Conclusion The clinical features of LyH are diverse, recurrent and so on. The misdiagnosis rate is high. Glucocorticoid treatment can significantly reduce the pituitary, the symptoms significantly improved pituitary function has been restored.