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目的研究接受药物洗脱支架治疗的早发冠心病(PCAD)患者近期预后。方法收集290例PCAD患者(男<55岁,女<65岁)和227例非冠心病对照者临床资料,对PCAD中行药物洗脱支架(西罗莫司或紫杉醇洗脱支架)植入治疗的180例患者(单支病变组62例及多支病变组118例)进行6个月随访研究。结果 PCAD组男性、高血压、糖尿病、吸烟、肥胖及饮酒比例及总胆醇、低密度脂蛋白胆固醇、载脂蛋白B、脂蛋白(a)及空腹血糖水平均高于非冠心病对照组(P均<0.05)。药物洗脱支架治疗多支病变组糖尿病比例高于单支病变组(P<0.01)。接受药物洗脱支架治疗的PCAD单支病变组及多支病变组术后6个月单一及复合心血管事件差异无统计学意义(P>0.05)。结论 PCAD患者临床心血管危险因素多,接受药物洗脱支架治疗后的近期预后较好。
Objective To investigate the short-term prognosis of patients with premature coronary artery disease (PCAD) receiving drug-eluting stents. Methods The clinical data of 290 PCAD patients (male <55 years old, female <65 years old) and 227 non-coronary heart disease controls were collected and treated with PCAD sirolimus-eluting stent (sirolimus or paclitaxel-eluting stent) Sixty-eight follow-up studies were performed in 180 patients (62 with single-vessel disease and 118 with multiple-vessel disease). Results The rates of male, hypertension, diabetes, smoking, obesity and drinking and the levels of total cholesterol, low density lipoprotein cholesterol, apolipoprotein B, lipoprotein (a) and fasting blood glucose in PCAD group were significantly higher than those in non-coronary heart disease control group P <0.05). Drug-eluting stents in the multi-vessel disease group had a higher proportion of diabetes than in the single vessel disease group (P <0.01). There was no significant difference in single and multiple cardiovascular events at 6 months after PCAE single-vessel lesion and multi-vessel lesion treated with drug-eluting stents (P> 0.05). Conclusions There are many clinical cardiovascular risk factors in patients with PCAD, and the recent prognosis after receiving drug-eluting stents is better.