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目的探讨尼尔雌醇治疗绝经后妇女复发性血尿的临床效果和可行性。方法将68例绝经后复发性血尿患者随机分成治疗组40例和对照组28例,治疗组应用尼尔雌醇,对照组应用抗生素和止血药物,疗程均为6个月,观察两组患者的复发率、子宫内膜厚度变化及不良反应等。结果治疗组疗程结束后3个月、6个月的复发率(分别为6.52%和4.35%)与对照组(分别为26.32%和47.37%)比较差异均有统计学意义(P<0.05);治疗组治疗前、后子宫内膜厚度间差异无统计学意义(P>0.05)。结论使用尼尔雌醇能够有效减少绝经后妇女复发性血尿的反复发作。
Objective To investigate the clinical effect and feasibility of nylestriol in the treatment of recurrent hematuria in postmenopausal women. Methods Sixty-eight patients with postmenopausal recurrent hematuria were randomly divided into treatment group (n = 40) and control group (n = 28). Nilestriol was used in the treatment group and antibiotics and hemostatic drugs were used in the control group. The course of treatment was 6 months. Recurrence rate, changes in endometrial thickness and adverse reactions. Results The recurrence rates (6.52% and 4.35%) in the treatment group at 3 and 6 months after the end of treatment were significantly different from those in the control group (26.32% and 47.37%, respectively) (P <0.05). There was no significant difference in the endometrial thickness before and after treatment in the treatment group (P> 0.05). Conclusion The use of nilestriol can effectively reduce the recurrence of recurrent hematuria in postmenopausal women.