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AIM:To investigate the expression of proliferating cellnuclear antigen(PCNA)and CD44mRNA in colorectalcancer with venous invasion and its relationship with livermetastasis.METHODS:Reverse transcriptase-polymerase chainreaction(RT-PCR)was used to detect the expression ofPCNA and CD44mRNA in 31 cases of colorectal cancer withvenous invasion.RESULTS:Positive expression rates of PCNA andCD44mRNA in colorectal cancer were higher than thosewithout liver metastasis(P<0.05 and P<0.01).In case ofcolorectal cancer with liver metastasis,strongly positive ratesof PCNA and CD44mRNA were 94.1% and 70.6 %,respectively,significantly higher than those without livermetastasis.There was a positive relationship between theexpressions of PCNA and CD44mRNA(r=0.67,P<0.05).CONCLUSION: Detection of PCNA and CD44mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells.
AIM: To investigate the expression of proliferating cell nuclear antigen (PCNA) and CD44 mRNA in colorectal cancer with venous invasion and its relationship with liver metastasis. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of PCNA and CD44 mRNA in 31 cases of colorectal cancer withvenous invasion.RESULTS: Positive expression rates of PCNA andCD44mRNA in colorectal cancer were higher than thosewithout liver metastasis (P <0.05and P <0.01) .In case ofcolorectal cancer with liver metastasis, and 70.6%, respectively, significantly higher than those without livermetastasis. There was a positive relationship between theexpressions of PCNA and CD44 mRNA (r = 0.67, P <0.05) .CONCLUSION: Detection of PCNA and CD44 mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells.