Kukhtin-Ramirez反应是有机化学中一类重要的极性反转反应.利用三价磷的还原性对α-羰基酮化合物进行极性反转,所生成的Kukhtin-Ramirez活性中间体在诸多转化中都展现出了其作为1,1-偶极子的化学性质.近年来关于该活性中间体的反应研究主要包括:极性X—H键插入反应、还原性加成反应、形式[2+1]环加成反应、形式[4+1]环加成反应、形式[4+2]环加成反应.这些转化为一些重要的多官能团化合成中间体及结构复杂的环状化合物提供了高效简洁的合成方法,凸显了Kukhtin-Ramirez极性反转反应在有机合成中的重要性. Kukhtin-Ramirez reaction is a kind of important polarity reversal reaction in organic chemistry.Using the reducibility of trivalent phosphorus to reverse the polarity of α-carbonyl ketones, the Kukhtin-Ramirez active intermediates formed in many transformations Have shown their chemical properties as 1,1-dipole.In recent years, the reaction on the active intermediates mainly include: polar X-H bond insertion reaction, reductive addition reaction, the form of [2 +1 ] Cycloaddition reaction, the formal [4 + 1] cycloaddition reaction in the form of a [4 + 2] cycloaddition.These conversions provide a number of important multifunctional synthetic intermediates and complexly structured cyclic compounds that provide efficient The succinct synthesis method highlights the importance of Kukhtin-Ramirez polarity inversion in organic synthesis.