乳腺癌是美国妇女最常见的恶性肿瘤和第2大癌症死因,2009年中估计有192 370个新发诊断病例同年死亡40 170人。尽管从1990年以来乳腺癌的病死率已经有了明显的下降,但在年龄20～59岁的女性中乳腺癌仍然是癌症死亡的主要原因[1]。三阴性乳腺癌(TNBC)在乳腺癌中大致占到 Breast cancer is the most common malignancy in the United States and the second leading cause of cancer deaths. In 2009, an estimated 192 370 newly diagnosed cases were reported deaths of 40 170 in the same year. Although the mortality rate of breast cancer has dropped significantly since 1990, breast cancer remains the leading cause of cancer death in women aged 20 to 59 years [1]. Triple negative breast cancer (TNBC) is roughly accounted for in breast cancer