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目的 探讨血清骨保护素 (OPG)水平与冠心病的关系。方法 冠心病组 6 4例及对照组 2 6例用ELISA法测定OPG水平。根据冠状动脉造影 (CAG)的结果将冠心病组分为单支、2支、3支病变组。冠心病的多个易患因素进行多因素Logistic回归等分析。结果 冠心病组患者血清OPG水平显著高于对照组 (P <0 0 5 ) ,且随冠状动脉病变支数的增加而升高 (P <0 0 0 1) ;血清OPG水平与年龄呈正相关 (r=0 4 7,P <0 0 0 1) ;多元回归分析显示血清OPG与冠心病严重程度有密切关系(OR =2 4 ;95 %的可信区间为 1 4～ 4 2 )。结论 OPG水平升高与冠心病、冠状动脉病变程度有关
Objective To investigate the relationship between serum osteoprotegerin (OPG) level and coronary heart disease. Methods Sixty-six patients in coronary heart disease group and 26 in control group were tested for the level of OPG by ELISA. According to the results of coronary angiography (CAG), coronary artery disease was divided into single, 2, 3 lesions. Multiple risk factors for coronary heart disease were analyzed by multivariate Logistic regression. Results Serum levels of OPG in patients with CHD were significantly higher than those in controls (P <0.05), and increased with the number of coronary lesions (P <0.01). Serum levels of OPG were positively correlated with age Multiple regression analysis showed that serum OPG was closely related to the severity of coronary heart disease (OR = 24; 95% confidence interval was 14 ~ 42). Conclusion The level of OPG is related to the severity of coronary heart disease and coronary artery disease