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目的 :探讨检测肝硬化患者载脂蛋白A I(ApoA I)、载脂蛋白B(ApoB)、透明质酸 (hyaluronicacid ,HA)和胆酸 (totalbileacid ,TBA)的临床意义。方法 :用ELISA法和放免法测定 40例肝硬化组和 2 0例非肝硬化组血清载脂蛋白、HA、TBA含量及它们之间的相互关系。结果 :肝硬化患者ApoA I、ApoB、HDL和TG含量下降 ,HA和TBA含量升高 ,与非肝硬化患者比较有显著性差异 (P <0 .0 5 ) ;ApoA I、ApoB含量与HA、TBA上升呈负相关。 结论 :ApoA I、ApoB含量可作为肝硬化患者病情监测的良好指标。
Objective: To investigate the clinical significance of detection of apolipoprotein A (ApoA I), apolipoprotein B (ApoB), hyaluronic acid (HA) and total bile acid (TBA) in patients with liver cirrhosis. Methods: Serum levels of apolipoprotein, HA and TBA in 40 cirrhotic patients and 20 non-cirrhotic patients were determined by ELISA and radioimmunoassay. Results: The levels of ApoA I, ApoB, HDL and TG in cirrhotic patients were decreased, while the contents of HA and TBA were increased in patients with cirrhosis compared with non-cirrhotic patients (P <0.05). The levels of ApoA I, TBA rise was negatively correlated. Conclusion: ApoA I, ApoB levels can be used as a good indicator of disease monitoring in patients with cirrhosis.