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本文报告了在环境流行病学调查的基础上，用病区粮食及燃煤进行大鼠氟中毒模型的复制，进一步探讨不同类型氟骨症的影响因素及发病机制，为制订有针对性的防治措施提供科学依据。实验用Wistar大鼠180只，随机分为6组，即高氟组、高氟加营养组、低氟组、低氟加营养组、煤烟污染组及对照组。结果表明，除对照组外，其余各组均出现氟斑牙．骨蛎X光片及病理组织学检查，高氟组出现骨疏松，并伴有骨转换征象，加营养可减轻骨病变程度，呼吸道吸入氟也可引起氟骨症，但病变较轻。引起不同类型氟骨症的主要因素是总摄氟量高、营养低下（蛋白质及钙摄入不足）和铝元素增多等。
This paper reports on the basis of environmental epidemiological investigation, replication of rat model of fluorosis with food and coal in ward, to further explore the influencing factors and pathogenesis of different types of skeletal fluorosis, in order to develop targeted prevention and treatment Measures provide a scientific basis. 180 Wistar rats were randomly divided into 6 groups: high fluoride group, high fluoride plus nutrition group, low fluoride group, low fluoride plus nutrition group, soot contamination group and control group. The results showed that, in addition to the control group, the remaining groups showed dental fluorosis. Osteoporosis X-ray and histopathological examination, high fluoride group osteoporosis, accompanied by signs of bone turnover, plus nutrition can reduce the degree of bone lesions, fluoride inhaled airways can also cause skeletal fluorosis, but lesser lesions. The main factors that cause different types of skeletal fluorosis are total fluoride intake, low nutrition (insufficient protein and calcium intake) and increased aluminum.