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目的分析清开灵注射液所致药物不良反应(ADR)情况。方法选取2010年1月—2014年6月纳雍县人民医院予以清开灵注射液治疗的患者693例,其中出现ADR患者61例。分析患者基本情况(性别、年龄)、原患疾病情况、用药情况、ADR临床表现及转归等。结果 693例患者中<14岁的ADR发生率最高(16.26%),>70岁的ADR发生率最低(12.24%);61例ADR患者中造成皮肤及其附件损伤21例(34.43%),其次为胃肠系统损伤16例(26.23%);61例ADR患者均痊愈。结论清开灵注射液发生ADR不可避免,临床工作中应加强合理用药,减少ADR的发生,以确保用药安全。
Objective To analyze the adverse drug reaction (ADR) induced by Qingkailing Injection. Methods From January 2010 to June 2014, 693 patients were treated with Qingkailing Injection in Nayong County People’s Hospital, of which 61 cases were ADR patients. Analysis of the basic situation of patients (gender, age), the original disease status, medication, ADR clinical manifestations and outcomes. Results The incidence of ADR was the highest (16.26%) in 693 patients and the lowest in ADR> 70 (12.24%). Twenty-one patients (34.43%) had skin and accessory injury in 61 ADR patients, and the second Sixteen patients (26.23%) had gastrointestinal injury, and 61 patients with ADR recovered. Conclusion Qingkailing injection is inevitable in ADR. In clinical practice, we should strengthen the rational use of drugs and reduce the occurrence of ADR to ensure the safety of medication.